despair

a state in which all hope is lost or absent; "in the depths of despair"; "they were rescued from despair at the last minute"; "courage born of desperation"

the feeling that everything is wrong and nothing will turn out well; "they moaned in despair and dismay"; "one harsh word would send her into the depths of despair"

abandon hope; give up hope; lose heart; "Don't despair--help is on the way!"